Josse-posten

The US–Iran ceasefire dies in a fourth wave of strikes, Ukraine’s fires march ever deeper into Russia, and fatal blazes ring the map from a Bangkok pub to the forests of Fontainebleau.

US–Iran War: Ceasefire Collapses in Fourth Strike Wave; Iran Hits Gulf Bases

Cargo ships anchored near the Strait of Hormuz off the eastern coast of the UAE, July 12. Photo: AFP

Trump has confirmed the June ceasefire is over. The US launched a fourth wave of strikes against Iranian missile systems around the Strait of Hormuz — CENTCOM says it hit 90 targets, with Iran’s health ministry reporting at least 14 killed — and Iran retaliated by striking US military bases in Bahrain, Kuwait and Jordan, a geographic expansion that brings the war directly to the Gulf Arab states hosting American forces. Tehran declared diplomacy “futile,” accused Washington of violating the ceasefire, and again said Hormuz is closed after a ship was struck; Trump rejected the claim and vowed to enforce freedom of navigation. Brent crude surged more than 4%. An Iranian newspaper ran a front page depicting Trump and Netanyahu in prison uniforms — a measure of how far the rhetoric has run alongside the missiles. (Deeper analysis — Mojtaba Khamenei’s rise, Iran’s losses in Iraq — in Investigations.)

Azov Campaign Reaches 90 Tankers in a Week; Russia Suspends Shipping, Crimea Squeezed

Video screenshot from a Ukrainian drone strike on a Russian shadow-fleet tanker in the Sea of Azov, part of the campaign that reached 90 vessels struck by July 12.

Ukraine’s drone campaign against Russia’s shadow fleet in the Sea of Azov reached 90 vessels struck since July 6 — 14 more overnight (10 tankers, four ferries), plus three ferries hit near Kerch — and Russia has now suspended all Azov shipping. The effect on Crimea is severe: Sevastopol was cut off from electricity entirely after strikes on substations, power rationing has spread across most of the peninsula, and fuel has climbed to roughly 380 rubles (~$5) a litre as the maritime supply route collapses. Russian milbloggers concede the Navy cannot reliably protect its own tankers — no unified convoy defence, only bureaucratic inertia. (Full Ukraine coverage below.)

At Least 27 Killed in Bangkok Bar Fire

Emergency personnel work next to casualties at the site of the deadly pub fire in Bangkok’s Chatuchak district. Photo: Reuters

A fire tore through a popular pub in Bangkok’s Chatuchak district around midnight, killing at least 27 and leaving 22 critically injured. Patrons were filmed running through flames to escape as a massive blaze engulfed the building. It is one of the deadliest venue fires Thailand has seen in years, reviving longstanding concerns about fire-safety enforcement in the country’s entertainment industry.

Indicator Value Change
S&P 500 (f) 7,587.75 -0.43%
Dow 30 (f) 52,846 -0.11%
Nasdaq (f) 29,670.50 -1.20%
Russell 2000 (f) 2,985.80 -0.27%
VIX 16.4 +9.12%
Gold 4,066.10 -1.16%
BTC $63,756.22 -0.03%
EUR/USD 1.1408 +0.05%
USD/NOK 9.7663 -0.19%
  • VIX +9.1% — the fear gauge jumps as the Iran ceasefire collapses (fourth strike wave, Gulf base retaliation; see above).
  • US futures broadly red, Nasdaq leading losses at -1.2%, as the widening US–Iran conflict weighs on risk appetite.

World

New Era for Gibraltar as 118-Year-Old Border Controls Removed

Gibraltar has removed its border controls with Spain for the first time since 1908, opening free movement between the British overseas territory and the EU. The agreement — years in negotiation after Brexit — is expected to deliver a significant economic boost on both sides, and marks a rare piece of post-Brexit diplomatic progress for the UK.

Europe’s Late-June Heatwave Killed 10,000+; UK Toll Among Worst Ever

Europe recorded roughly 10,000 excess deaths during the late-June heatwave, according to new data. In the UK, thousands more are estimated to have died during the unprecedented May and June heat — among the deadliest heat episodes ever recorded in Britain. The figures underscore accelerating climate-related mortality even in historically temperate regions, where health and infrastructure systems are poorly adapted to sustained extreme heat.

Spain Wildfire Toll Rises to 13; British Couple Found Burned in Ravine

The death toll from Spain’s Almería wildfire has risen to at least 13, with five now believed to be British. A British couple were found badly burned and semi-conscious in a ravine, airlifted to hospital after a two-hour rescue by the Guardia Civil. Survivors describe “a sea of black” where homes once stood.

Fire-Bomber Planes Battle Wildfire of ‘Exceptional Scale’ Near Paris

An unusually large wildfire erupted in the Fontainebleau forest near Paris, rapidly burning over 800 hectares, forcing village evacuations, partially closing a major highway and disrupting high-speed rail. France deployed firefighting aircraft from the south — the first time such planes have been used in the Paris region. The blaze reflects how climate-driven fire risk is creeping into parts of northern Europe long considered largely safe.

Israel Sets October 27 Elections; Netanyahu to Run Again

Israeli PM Benjamin Netanyahu speaks at a ceremony in occupied East Jerusalem. Photo: AFP

Israel’s parliament has set October 27 for national elections. Netanyahu, the country’s longest-serving leader, confirmed he will seek another term — his first electoral test since the Gaza war thrust his government into severe international isolation and triggered ICC arrest-warrant proceedings. The vote will be a referendum on his handling of the conflict and its aftermath.

Venezuela: Earthquake Toll Reaches 4,490 as Rubio Gains Sweeping Authority

Venezuela’s earthquake death toll has climbed to 4,490. In a parallel development, Secretary of State Marco Rubio has been granted unprecedented authority over US policy toward Venezuela — centralising decision-making over one of Washington’s most complex crises in a single official at a moment when the country is simultaneously managing a massive natural disaster and a deepening political crisis. (How far that control now reaches — Investigations.)

Also today

Migration
South Africa says it has deported more than 53,000 undocumented migrants after widespread anti-immigration protests — one of the continent’s largest such campaigns — BBC
More than 16,000 refugees have been unable to reunite with families in the UK since the family-reunion route was suspended, leaving many in conflict zones or resorting to smugglers, per the Refugee Council — Guardian
Europe
France opens a terrorism probe after firearms were found in a car near Paris, prompting a major security response — CTV · r/worldnews
France moves to ban advertising for fossil fuels — oil, gas and coal — following the logic of tobacco-ad bans — Le Monde · r/worldnews
Middle East
Ro Khanna accuses the IDF of “lying” about the West Bank incident in which settlers and soldiers held up his van; Israel’s ambassador calls it a stunt, and the congressman now faces pro-Israel attacks — Guardian · Al Jazeera
Asia-Pacific
New Zealand joins a Pacific defence alliance, welcomed by Australia as a step toward regional security cooperation amid concerns over Chinese influence — 1News · r/worldnews
Health
First patients enrolled in a record-speed Ebola treatment trial in DRC’s Ituri region — launched just six weeks after the outbreak was declared, testing two drugs against a disease with no approved treatment — Guardian
US politics
Mitch McConnell reveals a fall led to his extended hospitalization, ending weeks of speculation; the 83-year-old says he is “regaining strength” but won’t return “quite yet” — Guardian · NPR

Ukraine

Deep-Strike Campaign Reaches 800+ km; Germany Funds 50,000 Strike Drones

A bright explosion lights up the night sky at the Mikhailovskaya oil depot in Stavropol Krai following a Ukrainian strike, July 12–13. Photo: Kyiv Independent

Ukraine struck the Syzran oil refinery in Samara Oblast — roughly 800 km from the front, capacity 8.5 million tons/year — overnight July 11–12, then set ablaze a LUKOIL depot in Stavropol Krai (~1,500 km away) the following night, with drones also triggering air-defence responses west of Moscow. Battle-damage assessments confirm the July 9 Tver depot strike destroyed three tanks and the July 10 Novatek Ust-Luga strike (1,100 km out) damaged its refining unit. Separately, Germany has committed to funding 50,000 strike drones — a major expansion of Ukraine’s long-range reach. Russian milbloggers warn the country relies on a Soviet-era air-defence model unable to intercept low-altitude drones, and that refinery and substation damage cannot be repaired quickly.

Russia Deepens Hold in Kostyantynivka as Azov’s ‘Operation Hell’ Dismantles a Rear Hub

Russian forces have secured a foothold across eastern Kostyantynivka (Teatralna to Bulgakov streets) and are now fighting near the central Metalurh Stadium and City Hospital No. 1 in the west; foliage and rubble are blunting Ukrainian drones while Russia’s glide-bomb campaign intensifies. Fighting is assessed to run at least through August. Meanwhile Ukraine’s 1st Azov Corps ran “Operation Hell” — a sequenced strike on a fuel logistics hub near Novoamvrosiivske (~110 km back, previously thought beyond reach): crews destroyed a railway crane, blocked the line by hitting a locomotive, knocked out the electrical substation, then struck the fuel tanks, forcing Russia to abandon the node. Some 257 combat engagements were recorded across all fronts in a day, heaviest on the Sloviansk, Pokrovsk and Kostyantynivka axes.

Zelensky Reshuffles Cabinet; Trump Softens on Ukraine After Intelligence Briefing

Zelensky announced that PM Denys Shmyhal will step down and that Yulia Svyrydenko will be reassigned — reports point to her becoming Ukraine’s new US ambassador — with the incoming cabinet explicitly tasked with executing Patriot interceptor production under US licences and building a European anti-ballistic shield. The reshuffle coincides with a notable shift in Washington: the Wall Street Journal reports Trump softened his Ukraine rhetoric after an intelligence briefing on Kyiv’s rapidly expanding long-range strike capabilities. On air defence, Poland transferred five Patriot interceptors, but Ukraine has not intercepted a single Russian ballistic missile in nine consecutive days amid critical shortages. On sanctions, EU ambassadors failed to agree the 21st Russia package — with Patriarch Kirill and Lukoil founder Alekperov reportedly dropped from the draft — pushing the decision to foreign ministers on July 13.

Senator Lindsey Graham Dies; Kremlin Propaganda Exploits an Ally’s Death

US Senator Lindsey Graham, 71 — one of the most vocal Republican advocates for Ukraine — has died after a brief and sudden illness, having visited Zelensky in Kyiv just days earlier. Russian state media promptly taunted Trump over his death; a Russian opposition figure alleged Kremlin involvement, though this is unverified and widely treated as speculation. Graham’s death removes a key institutional voice in the Senate for continued military support and for arming Ukraine with more advanced weaponry.

Also today

  • Italy dismantled a Russian intelligence network gathering data on Ukraine’s air-defence systems from Italian soil — a concrete example of Russia’s hybrid campaign on NATO territory — Kyiv Post · r/worldnews
  • Zelenskyy discloses that China privately warned Putin not to use nuclear weapons in Ukraine — a rare glimpse of Beijing drawing red lines despite its de facto alignment with Moscow — Politico · r/geopolitics
  • Ukraine is, for the first time, generating tangible internal economic pain inside Russia — refinery, depot and port strikes disrupting the domestic economy — and is betting winter energy dynamics open a window to pressure Putin — Politico · r/geopolitics
  • North Korea’s Kim Jong-un fires senior military officers in a corruption purge — read as a warning shot amid large DPRK troop deployments to Russia — SCMP · r/worldnews

Investigations

Rubio Runs Venezuela as a De Facto Viceroy From Washington

Six months after US commandos blew open Maduro’s bedroom door and captured him in a night raid, Secretary of State Rubio now effectively controls Venezuela’s finances, natural-resource distribution and government, per NYT interviews with more than a dozen officials in both capitals. He communicates directly with acting president Delcy Rodríguez on WhatsApp in Spanish — trading gossip, birthday greetings and selfies. The piece compares his role to L. Paul Bremer III running occupied Iraq in 2003. Trump reportedly floated Rubio becoming Venezuela’s next leader; aides say he was joking. A vivid snapshot of American imperial power in the Trump era. (Earthquake toll and Rubio’s expanded powers in World.)

Mojtaba Khamenei Takes Power, Pledges ‘Divine Mission’ of Revenge

A couple pass a large portrait of Supreme Leader Ayatollah Mojtaba Khamenei on a street in Tehran. Photo: BBC

In his first public statement since the war began, Iran’s new Supreme Leader Mojtaba Khamenei — son of Ali Khamenei, killed in the February 28 opening strikes — declared that vengeance is “the will of the nation”: “Whether we are present or not, it will come to pass.” His father was buried at the Imam Reza shrine in Mashhad on July 9 after six days of mourning, with funeral crowds carrying placards calling for Trump’s assassination. Trump warned any such plans would see the US “decimate and destroy all areas” of Iran. Mojtaba has not been seen in public since before the war and is rumoured to have been disfigured in the strike that killed his father.

Iran Is Losing Iraq: PMF Splinters, Baghdad Asserts Sovereignty

Foreign Affairs argues that even as Iran may emerge stronger from the wider war, it is losing its dominant position in Iraq. Sadr’s Saraya al-Salam became the first Popular Mobilization Forces faction to fully disarm and integrate into the Iraqi state; Asaib Ahl al-Haq followed. New Iraqi PM Ali al-Zaidi, endorsed by Trump, has made disarmament a priority, and the Shiite clerical establishment in Najaf refused to issue a religious summons to fight for Iran — putting Iraqi national interest above the axis of resistance. The pattern echoes Iran’s Syria failure: “by pursuing its own military aims through a reluctant host and failing to read the warning signs, Iran is repeating the error in Iraq.”

Russia’s Hybrid Coercion Is Coherent Strategy, Not Random Incidents — HCSS

A new Hague Centre for Strategic Studies report argues Russia’s sustained campaign of sabotage, drone incursions and assassinations across Europe is not vaguely-defined “hybrid warfare” but a deliberate coercive strategy aimed at reducing European support for Ukraine. It is selective — targeting states that back Ukraine, sparing those that don’t — and timed to key political decisions (case studies: the 2025 Belgian and Polish drone incursions). Europe is caught in a strategic trap: Russia picks when and where to strike; Europe must defend an ever-expanding target set. The central recommendation inverts the logic: every sub-threshold attack should trigger more support for Ukraine, making the campaign self-defeating.

How Hizballah’s Three-Front Risk Strategy Forced Lebanon Into the Iran Deal

War on the Rocks dissects how Hizballah’s campaign wasn’t merely tactical but a coherent “risk strategy” operating against three audiences at once: generating domestic political pressure in Israel; keeping uncontrolled escalation credible for Iran’s negotiating leverage; and making continued Israeli operations a liability for a US president eager to close a deal. Iran insisted Lebanon be included in any framework — and without Hizballah’s documented, escalating costs, Washington could have dismissed that demand as rhetorical. “Every casualty, every rocket siren, every failed intercept transformed Lebanon from a peripheral theater into a demonstrable risk to broader diplomatic negotiations.”

Also today

  • China halts helium exports amid the Iran war to protect its own semiconductor manufacturing — a strategic resource move that will squeeze already-stressed global chip supply chains — AP · r/geopolitics
  • An RFA investigation details how Chinese tech giants exploit gaps in ICANN’s domain-governance rules to target diaspora activists abroad — technical internet infrastructure turned into an instrument of transnational repression — RFA · r/geopolitics
  • New research (NYT) documents terrorist groups — including Boko Haram — using AI chatbots not just for propaganda but for bomb construction and attack planning, a qualitative shift from radicalization tool to direct enabler of violence — NYT · r/geopolitics

Tech

Closing a Three-Year-Old Issue in the Gleam Compiler With Rust Arenas

A post-mortem on a long-standing correctness bug in the Gleam compiler, resolved by switching an internal data structure to Rust memory arenas. The write-up explains why the original approach (heap-allocated nodes with Rc pointers) made the bug hard to reason about, and how arena allocation — by tying object lifetimes to a single region — both fixed the bug and simplified the code. A clean case for reaching for arenas as a structural solution rather than a performance optimization.

Quadrupling Code Performance With a “Useless” If Statement

A deep dive into how inserting an apparently redundant conditional can quadruple throughput on certain hot loops — the explanation runs through branch prediction, CPU pipeline behaviour, and how the compiler’s view of a branch differs from hardware execution. A clean case study in the gap between source semantics and actual machine behaviour.

Good Tools Are Invisible

Gingerbill (creator of the Odin language) on what distinguishes good tools from bad: the best ones disappear into the task and stop demanding attention from the user. The essay draws on philosophy of technology and his experience designing Odin’s toolchain — a direct counterpoint to tools that impose their own workflow, aesthetics or mental model. Relevant to the ongoing conversation around editor and language tooling design.

SQL Injection to RCE — Two Exploit Chains Worth Studying

Header graphic for the Apple SQL-injection-to-RCE research writeup. Image: ProjectDiscovery

Two full exploitation writeups. ProjectDiscovery chained a SQL injection into full remote code execution on an Apple production server via the bug-bounty program — reconnaissance, injection-point discovery, database enumeration, and the escalation path to RCE, all documented. Separately, mrbruh details an unauthenticated RCE in the Motorola MR2600 home router, reachable from the local network with no credentials: vulnerable endpoint, payload construction and shell acquisition. Relevant to anyone running consumer routers at home.

Browsers Do Floating-Point Math Differently on Every OS — Anti-Bot Systems Read the Bits

Because of OS-level math-library differences, floating-point operations in browsers produce subtly different bit patterns on Windows, macOS and Linux even for identical inputs. Anti-bot fingerprinting systems exploit these differences to identify platform/browser combinations even when user-agent strings and other signals are spoofed. The piece documents specific trigonometric operations that diverge across platforms and how fingerprinting services encode them as detection signals.

Slow Software: The Case for Deliberate Friction in Critical Systems

A SIGOPS piece by Irene Y. Zhang argues that AI-accelerated development has severed a historical link between development speed and system criticality — complex, high-stakes software used to be hard to build, which acted as a natural selection filter. She proposes a “slow software movement” to reintroduce deliberate friction for high-dependency infrastructure, and extends the critique to research: cheap prototyping floods conferences with underconsidered work and burns out reviewers.

Automation Without Understanding: AI Disproves Theorems While We Defund the Verifiers

An arXiv essay argues that AI generating research-level mathematics and the simultaneous US defunding of mathematicians are on a collision course. The core claim: mathematical capacity — the ability to verify, interpret and challenge proofs — is strategic infrastructure, not a byproduct of theorem production, and is hard to rebuild once lost. The May 2026 AI disproof of an Erdős conjecture anchors the argument. The author’s recommendation: require AI reasoning systems to output formally verifiable claims rather than natural-language arguments.

arXiv · HN

Research Notes: Causal Interpretability, Sparse Attention, and a Diversity Prompt

Benchmark chart comparing Flash-MSA vs Flash-Attention training-step performance across sequence length. Image: Flash-MSA

Three research items worth a look. Causal interpretability: researchers bring Pearl’s do-calculus and structural causal models to mechanistic interpretability of LLMs, aiming to identify which attention heads and MLP layers cause particular reasoning behaviours rather than merely correlate — early results look better at finding genuine computational pathways, though frontier-scale remains open. Flash-MSA: custom CUDA kernels for million-token sparse attention that recover the theoretical FLOPs advantage of sparsity on real hardware, competitive with Flash Attention in wall-clock training time. Verbalized Sampling (ICML 2026): asking a model to “generate multiple responses and assign probabilities to each” unlocks diversity that RLHF suppressed — the authors trace mode collapse to “typicality bias in preference data” and show a 1.6–2.1× diversity gain in creative writing, no fine-tuning, no quality or safety regression.

Also today

Dev tools
Evan Martin’s hands-on Jujutsu (jj) tutorial — the most authoritative walkthrough of the git-compatible VCS, covering the change/commit distinction, revsets and conflict handling — Evan’s jj Tutorial · Lobsters
Homelab
A homelab overhaul log — fishing Cat6 through attic and garage, replacing the ISP router with a UniFi stack, and consolidating a server into an HPE rack, with a Glance dashboard finally all-green — Tim Harek · Lobsters
Culture
Hacker Fables, a satirical cyberpunk novella distributed as a Unix man page (and GNU Info) — the format is the joke, the point and part of the content; read via man hacker-fablesHacker Fables · Lobsters
Sam Neill, the New Zealand actor best known for Jurassic Park, has died at 78, two years after disclosing a stage-three non-Hodgkin lymphoma diagnosis — Guardian · HN

AI & Automation

Nobel Laureate John Jumper (AlphaFold) Leaves DeepMind for Anthropic

John Jumper — who shared the 2024 Nobel Prize in Chemistry for AlphaFold, the model that cracked the protein-structure problem — is leaving Google DeepMind for Anthropic. He joins a recent string of high-profile hires that includes Jelani Nelson (UC Berkeley CS chair, whose algorithms lectures have 21M YouTube views) and several senior researchers from Google. The pattern suggests Anthropic is building serious scientific depth, likely aimed at biology and drug discovery beyond pure language modeling.

Anthropic Rounds Out the Lineup: Sonnet 5 for Agents, Claude Science for Researchers

Two launches from June 30. Claude Sonnet 5 targets agentic workloads at frontier performance but lower cost — positioned as the workhorse for high-volume pipelines. Claude Science is a specialized workbench for researchers that integrates common scientific tools and packages, produces auditable artifacts, and provides flexible compute access. Notably, Claude Science bets on workflow integration rather than a new model — Anthropic is framing it as winning scientists by meeting them in their toolchain rather than asking them to adapt to a chat interface.

Anthropic Reflect: Claude Shows You How (and How Much) You Use It

The Claude Reflect dashboard — topic breakdowns, task-type distributions and temporal patterns. Image: Anthropic

A new beta feature in Claude settings (for Memory-enabled Free/Pro/Max users): a personal usage dashboard showing topic breakdowns, task-type distributions and temporal patterns across 1–12 month windows. It also evaluates your “4D AI Fluency” — Delegation, Description, Discernment, Diligence — with examples from your own history, plus quiet-hours and break reminders. Anthropic worked with MIT Media Lab and Boston Children’s Hospital researchers, and excludes health conversations from analysis. An unusual move: helping users set boundaries on their AI use rather than maximizing engagement.

Claude Tag: Persistent, Multiplayer Claude Inside Your Slack Channels

Hero image for Claude Tag — Anthropic’s multiplayer Slack agent integration. Image: Anthropic

Anthropic launched Claude Tag (June 23), a Slack-native agent that works differently from chatbots: one @Claude instance is shared across everyone in a channel, builds persistent context from channel history and connected data sources, and can be handed tasks that run asynchronously. With “ambient” mode enabled, it proactively surfaces relevant information unprompted, accumulating tacit knowledge about team workflows over time. It’s Anthropic’s clearest move toward the “AI teammate” paradigm as opposed to a per-user assistant.

Mythos 5: Government Export Control, Then Released

In June the Trump administration issued a directive suspending access to Anthropic’s Fable 5 and Mythos 5 — its most capable safety-focused offering — citing export-control concerns. The standoff drew comparisons to PGP-era export restrictions, while Asian AI startups rushed to fill the gap. After weeks of negotiations, the administration first released Mythos access to 100+ US companies and agencies, then dropped the restrictions entirely. Anthropic called it its “first taste of the Trump admin’s new AI regulation regime” and is reportedly deepening pre-release government collaboration and information sharing.

Fable 5 Returns With a Cross-Industry Jailbreak Severity Framework

After its government-mandated suspension, Anthropic redeployed Fable 5 on July 1 alongside a proposed industry standard for scoring jailbreak severity — co-developed with Amazon, Microsoft, Google and other Glasswing partners. The framework scores jailbreaks on four dimensions (what’s unlocked, how broadly, how quickly it reaches real-world harm) to help developers triage disclosures, calibrate responses and communicate risk to regulators. Anthropic also stood up a 24/7 team to monitor jailbreak submission channels — safety infrastructure it frames as the precondition for shipping highly capable models, a direct response to the critique that SOTA guardrails fail under adversarial pressure.

Competitive Pressure: Fable 5 Metered Billing, GPT-5.6 Sol, and Grok 4.5

The subscriber economics are shifting fast. Anthropic’s Fable 5 moves to metered token billing for all consumer subscribers on July 19 (the deadline extended twice from July 12): after that, Pro and Max holders lose flat-rate access and must buy per-token credit packs — while competitors keep flat-rate tiers. Meanwhile GPT-5.6 Sol posts a benchmark that landed after last edition: 53.6 on Agents’ Last Exam (long-running professional workflows across 55 fields), beating Fable 5 by 13.1 points, and by 11.4 even at medium reasoning for roughly a quarter of the cost; a new ultra inference mode coordinates parallel agent workstreams. And Grok 4.5, trained alongside Cursor, launches at $2/$6 per million tokens — about a quarter of Fable 5’s cost — with SpaceXAI claiming 2× token efficiency. The Cursor co-training is notable: one of the first models explicitly trained to excel in an agentic IDE rather than benchmarked on it after the fact.

Also today

  • unsnooze — a CLI that monitors AI coding agents in tmux/Zellij, detects usage-limit stalls, records the reset time, and auto-injects a resume command the moment quota clears (survives laptop sleep). Native Claude Code support via hooks, plus Codex CLI, Grok Build, Qwen Code, Kimi CLI and OpenCode via scrape adapters — GitHub · r/ClaudeAI
  • Zer0Fit — wraps Google’s TabFM (zero-shot tabular classification/regression) and TimesFM 2.5 forecasting into one Docker container served over MCP; point Claude Code or Codex at a CSV, no fine-tuning needed (TabFM is non-commercial license) — GitHub · r/MachineLearning
  • A token-counting study finds Claude Code burns ~33K scaffold tokens on a cold first turn vs OpenCode’s ~7K (4.7×), and rewrites its cache prefix mid-session for up to 54× more cache-write tokens — identical correct outputs, so pure cost, not quality; the gap compounds badly with CLAUDE.md, MCP servers and subagents (one jumped 121K→513K) — Systima · HN

Long COVID & ME/CFS

First Direct Structural Evidence of Dopamine Nerve-Terminal Loss in Long COVID Striatum

PET imaging of the striatum in Long COVID patients reveals significantly reduced VMAT2 density — a marker of presynaptic dopaminergic neuron integrity — across all major striatal regions versus healthy controls. Lower VMAT2 in the ventral striatum correlated with loss of motivation, in the dorsal putamen with slowed movement, in the caudate with memory impairment. This is the first in-vivo structural evidence that dopaminergic neurons are directly injured — not merely functionally suppressed — in LC. Senior author Jeffrey Meyer (CAMH) suggests repurposing dopamine precursors or MAO inhibitors as a rational next step. The paper explicitly frames LC as “at least in part, a disorder of the brain’s dopamine system” — directly relevant to fatigue, motivation deficit and motor slowing.

Structural Vagal Cholinergic Denervation Confirmed in Long COVID Gastric Mucosa

Acanfora et al. (IJID, 2026) provide the first in-vivo morphological evidence of selective cholinergic nerve-fiber loss in Long COVID gastric mucosa — reduced VIP-positive mucosal fiber density and narrowed nerve-bundle width compared to controls. The key implication: autonomic dysfunction in LC is not purely functional (antibody-mediated or signalling impairment) but reflects structural nerve destruction. For a patient with maxed-out muscarinic M3/M4 autoantibodies (>40 U/ml), this sharpens the question of whether the AAbs drove or resulted from this damage — and whether removing AAbs alone could restore autonomic function if the underlying cholinergic innervation is already structurally compromised.

Tracking

  • ANKTIVA COVID-4.019-Long (Chan Soon-Shiong, NCT07123727) — trial window closed July 2026; no results yet
  • ANKTIVA INTERRUPT_LC (UCSF, NCT07108036) — ongoing, October 2026 completion
  • ADDRESS-LC (bezisterim, BioVie) — fully enrolled May 2026; topline expected late summer 2026
  • REVERSE-LC (baricitinib, Phase 3) — recruiting at 17 sites; neurocognition data expected Nov 2026
  • Rapamycin trials (Mount Sinai/Putrino + Simmaron) — both Phase 2; results expected Nov 2026
  • RESILIENCE (ensitrelvir prevention, Japan, n=2000) — data collection completed Jun 2026; results expected Dec 2026
  • Daratumumab “ResetME” RCT (Haukeland) — recruiting; ongoing funding gap; results ~2027
  • TURN-Long COVID (IA, Amsterdam UMC) — recruiting, AAb-stratified; Dec 2027 completion
  • EXTINCT post COVID (IA, Hannover) — enrollment complete, no results yet
  • Sipavibart RCT (Klimas/NSU) — ongoing; primary completion Dec 2026
  • Locci GC B-cell dysregulation (Penn/PolyBio) — PolyBio May 2026 presentation; no preprint yet
  • Brodin WGS severe LC (Karolinska/PolyBio) — PolyBio May 2026 presentation; no preprint yet
  • IVIg RECOVER-AUTONOMIC arm — no results yet; paper expected “in coming months”
  • Larazotide (AT1001) Harvard Phase 2a — interim shows improvement in sleep/fatigue/CV; full data collection ongoing
cd ~/repos/josse-posten && claude --resume cbefb668-942c-4d4c-a602-5fd65ce1ed38